So far, 3-aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6×H)-ones were identified as selective inhibitors of CHIKV nsP1 activity, both in cell culture infection models and in in vitro assays with purified Venezuelan equine encephalitis virus (VEEV) nsP1 (24, 25). The gene discussed is SH2D3A; the disease is infection.