Interestingly, a very recent study found that influenza A and B viral infection stress reduce levels of SUMOylated (small ubiquitin-like modifications) TRIM28/KAP1 protein, which is a major epigenetic repressor of ERVs, resulting in up-regulation of immunostimulatory ERV sequences and up-regulation of innate immune response genes (Schmidt et al, 2019). This evidence concerns the gene TRIM28 and viral infectious disease.