TARDBP and amyotrophic lateral sclerosis: Significantly, more than 95% of all ALS patients (ALS-TDP) are characterized by enhanced cleavage of TDP-43 to generate TDP-35/ TDP-25 fragments, by accumulation of ubiquitinated TDP-43/phosphorylated TDP-43, and by formation of ubiquitin(+), TDP-43(+) aggregates in the cytosol [38, 48].