Second, there was an age-dependent enhancement of cleavage of TDP-43 to generate 35-kDa and 25-kDa fragments in the spinal cord of post-symptomatic N390D/+ mice (Fig. 3b), which was characteristic of the spinal cord of ALS-TDP patients [49, 56]. Here, TARDBP is linked to amyotrophic lateral sclerosis.