High expression of LUCAT1 reduced DNA damage in HCT-116 cells both under normoxia and under hypoxia or CoCl2 treatment, which implicated that LUCAT1 might have a role in chemoresistance of hypoxic CRC cells (Fig. 6a, Additional file 1: Figure S15A and B). This evidence concerns the gene LUCAT1 and colorectal carcinoma.