The expression of CD248 and Sca-1 was negatively regulated, and the expression of ITGA8 was positively regulated by transforming growth factor (TGF)-β, which plays a critical role in the progression of fibrosis of IPF [15–18], suggesting that expression of CD248 and ITGA8 may be potentially changed in the pro-fibrotic state. This evidence concerns the gene CD248 and idiopathic pulmonary fibrosis.