Herein, we have no data on the cellular sources of IL-27 in human falciparum malaria, but notably, IL-27 levels were strongly correlated with plasma levels of IP-10 and sCD25 in patients with falciparum malaria, further suggesting a relation of IL-27 to T cell activation in malaria. Here, CXCL10 is linked to Plasmodium falciparum malaria.