BRF2 and cancer: Furthermore, study on expression ofBRF2 in patients with esophageal squamous cell cancer (ESCC) proved that higher expressionof BRF2 was prevalent in ESCC, which have a relationship with deeper tumor invasion andmicrovessel density.23 Although BRF2 has been identified as the key protein in cancer development, the clearmechanisms that how it effects are still waiting to find out.