Indeed, a line of studies demonstrated that zinc treatment could induce apoptosis through loss of mitochondrial membrane integrity, release of cytochrome c, increasing levels of BAX and/or BAX/BCL2 ratio and activation of caspase-9 and caspase-3 in a variety of PCa cell lines, including PC-3, HPR-1, 22Rv1, LNCaP and DU145 [69,70,76,86,87,88]. The gene discussed is BCL2; the disease is posterior cortical atrophy.