F2R and cancer: EVs are be considered as integrators of tissue physiology and whole-body homeostasis [88,89] EVs secretion is induced in response to extracellular signals such as ATP, interleukins, depolarization, thrombin receptor activation or by cell stress [90,91] Exosome secretion meanwhile can be induced by stress condition, micronutrient starvation, infection or cancer [92].