SOST and metabolic syndrome: Recently, study conducted by Wong et al. (2019) demonstrated that treatment with annatto or palm T3 modulated osteocyte-related bone peptides (characterized by lowering of RANKL, sclerostin (SOST), Dickkopf-related protein (DKK)-1 and fibroblast growth factor (FGF)-23) in a rat model of bone loss induced by MetS [163].