SRCAP is an AT-hook containing remodeling factor that catalyzes this substitution; heterozygosity for a truncated allele at this locus leads to the Floating-Harbor syndrome, a developmental disorder with altered craniofacial features (sometimes with cleft lip) and other abnormalities, including bone growth delay, and diminished stature and weight during early childhood. The gene discussed is SRCAP; the disease is Floating-Harbor syndrome.