HMGA2 and neurofibromatosis type 1: In cells of neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors, HMGA2 knock-down impaired cell cycle, led to a reduction in the percentage of dividing cells and to arrest in G0/G1 phase; in addition, there was an increase of apoptotic cells, an increased BAX1 expression, and a decrease in the expression of BCL-2 and of Cyclin D1 (related to the G0/G1 phase), suggesting that knock-down of HMGA2 function leads to apoptotic cell death [188].