At the time of writing this manuscript (December 2019), 62 studies on IL-17A neutralization were found in the online resource provided by U.S. National Library of Medicine (clinicaltrials.gov) related to established indications (psoriatic arthritis, rheumatoid arthritis with inadequate response to anti-TNF agents), but also to other indications, such as pyoderma gangrenosum, moderate-to-severe Crohn’s disease, relapsing-remitting sclerosis, and dry eye. Here, IL17A is linked to psoriatic arthritis.