Preliminary results for the cellular models suggest that CUFH isoflavones exhibit anti-metastatic effects in ERα-negative and ERα-positive cells, so we are proposing that these effects were exerted without ERα nuclear estrogen receptor involvement, and T. pratense isoflavones intake could be an effective dietary supplement for breast cancer patients, reducing cell migration and invasiveness. This evidence concerns the gene ESR1 and breast carcinoma.