YAP/TAZ mediate a plethora of transcriptional responses to the mechanical properties of the ECM and to cell geometry, including: mesenchymal stem cell, keratinocyte and pancreatic progenitor differentiation; endothelial proliferation vs. apoptosis; fibroblast activation and senescence; organoid growth in defined matrices; cancer cell proliferation [4]. Here, YAP1 is linked to cancer.