YAP/TAZ mediate a plethora of transcriptional responses to the mechanical properties of the ECM and to cell geometry, including: mesenchymal stem cell, keratinocyte and pancreatic progenitor differentiation; endothelial proliferation vs. apoptosis; fibroblast activation and senescence; organoid growth in defined matrices; cancer cell proliferation [4]. This evidence concerns the gene WWTR1 and cancer.