IL6 and irritable bowel syndrome: In this way, besides the eight-item immunological biomarker panel described by Mujagic et al. [11], which proposed and validated interleukin 1-beta, interleukin 6, interleukin 12p70, tumour necrosis factor-α, chromgranin A, human beta-defensin 2 (HBD2), calprotectin, and caproate in a multitest IBS panel, many studies described differentiating biomarkers.