In tonsils from IM patients, a prevalence of CD8+ T cells was proved [31], whereas in established EBV infection, at least 20% of the CD8+ T cell population is specific for EBV in some tonsils, mostly against latent antigens [32], but there are preferentially located at the subepithelial region, not at the GC [15,33].Therefore, CD8+ T cell response may be mostly involved in the control of EBV infection in this specific region. Here, CD8A is linked to Epstein-Barr virus infection.