STAT3 and T-cell large granular lymphocyte leukemia: Activating mutations in the SH2 domain of STAT3 (Y640F, D661Y/V) and STAT5B (N642H) were also described in T-LGL leukemia which is a chronic lymphoproliferative disorder characterized by the expansion of some cytotoxic T cell or NK cell populations (Figure 2) [95,96,97].