BCL2-family members, cell cycle-regulated genes, proto-oncogenes such as PIM1, c-MYC, BCL6, and genes involved in cytokine receptor signaling or immune response are often targets of STAT3/STAT5-mediated transcription in hematopoietic cancers [141]. This evidence concerns the gene STAT5A and hematopoietic and lymphoid cell neoplasm.