Additionally, the main biochemical pathways that influence diabetes include: the (i) polyol pathway; (ii) protein kinase C (PKC) activation; (iii) advanced glycation end-products (AGEs) pathway induced by their accumulation; (iv) activation of the hexosamine pathway; (v) oxidative stress, and (vi) expression of growth factors, such as vascular endothelial growth factors (VEGF) [5,6,7]. The gene discussed is VEGFA; the disease is diabetes mellitus.