Other agents, such as indomethacin, a COX inhibitor; nimesulide, a COX-2 selective inhibitor; sesamol, a COX-2 suppressor; and apocynin, an NADPH oxidase inhibitor, have been shown to significantly reduce the number of intestinal polyps in the middle to distal parts of the intestine [25,26,27,28]. The gene discussed is FMO5; the disease is intestinal polyp.