Moreover, treatment of HCT116 human colon cancer cells with 10,000 μM NZ-419 for 24 h decreased H2O2-induced Nrf2 promoter transcriptional activity by 56% (p < 0.01), respectively, compared with the control value in cells treated with H2O2 alone (Figure 2A). Here, NFE2L2 is linked to malignant colon neoplasm.