In addition, PINK1-deficienct mice exposed to intratracheal instillation of bleomycin had impaired activity of mitochondrial ETC complex I and IV activity leading to mitochondrial dysfunction, along with an increased susceptibility to develop lung fibrosis through upregulation of cytokine TNFα and downregulation of cytokine IL-10 [19,52]. The gene discussed is PINK1; the disease is pulmonary fibrosis.