PPARGC1A and pulmonary fibrosis: Moreover, the use of active thyroid hormone T3 has been suggested as potential therapy in lung fibrosis, Yu et al. reported that in mice models of pulmonary fibrosis administration of aerosolized T3 offered regenerative properties by inducing PGC-1a and PINK1, leading to mitochondrial biogenesis and restoration of mitochondrial function and attenuation of apoptosis [20].