COL4A4 and neoplasm: The expression of selected genes encoding extracellular matrix and basal lamina components (COL1A1–collagen I, COL4A4–collagen IV, LAMC2–laminin gamma), and proto-oncogenes (CTHRC1–collagen triple helix repeat containing protein 1, WNT7B–Wingless-Type MMTV Integration Site Family, Member 7) were not significantly changed in optiCA1 overexpressing tumor cells (Figure 2a).