In the study of Ganel et al. (2006) employing mouse model of ALS, it induced the selective expression of GLT-1 in vitro and in vivo, which was associated with a marked increase in dihydrokainite sensitive Na+-dependent glutamate transport protecting MNs in an in vitro model of chronic excitotoxicity and prolonging the survival of SOD1G93A mice. Here, SLC1A2 is linked to amyotrophic lateral sclerosis.