TARDBP and amyotrophic lateral sclerosis: Interestingly, the changes in TDP-43 expression and its solubility were also observed in mSOD1G93A model of ALS, where TDP-43 created similar cytoplasmic aggregates [157], as well as in the glial cells of Drosophila TDP-43D169G, G298S, A315T, N345K model of ALS [158].