C9orf72 and amyotrophic lateral sclerosis: For example, ALS cases that are caused by microsatellite expansions in C9ORF72 show intranuclear RNA foci [31], distinctive cytoplasmic inclusions that are derived from dipeptide repeat proteins (DPRs) [32,33], as well as p62-positive; largely TDP-43-negative neuronal cytoplasmic inclusions that predominantly occur in the cerebellum and hippocampus [34].