Patients with CAPS suffer recurrent episodes of fever and IL1B-mediated systemic inflammation involving skeleton, joints, eyes, muscles, skin, etc. Three clinical manifestations are found in the CAPS family: familial cold autoinflammatory syndrome (FCAS), Muckle–Wells syndrome (MWS) and chronic, infantile, neurological, cutaneous and articular syndrome (CINCA) (also known as neonatal-onset multisystem inflammatory disease (NOMID)), in order of increasing severity [130]. Here, IL1B is linked to familial cold autoinflammatory syndrome.