In addition, in Drosophila, it was demonstrated that the TFIIH complex plays a direct role in regulating the fly homologue of human MYC. MYC in humans is a proto-oncogene that is overexpressed in a large number of different types of tumours, and part of its role in oncogenesis is to over-activate a large number of genes [50]. This evidence concerns the gene MYC and neoplasm.