In glioma, the transfer of linc-CCAT2 to endothelial cells via glioma-derived exosomes resulted in the promotion of angiogenesis via the upregulation of VEGF, TGFβ, and Bcl-2 as well as a reduction of apoptosis via Bax and caspase-3 in vitro [58]. Here, CASP3 is linked to central nervous system cancer.