With the hypothesis that KCC2 function is dysregulated in the HD brain, the authors confirmed by co-immunoprecipitation that both wild-type and mHTT interact with KCC2 [85], but not NKCC1, in hippocampal brain lysates prepared from wild-type and an HD transgenic model, the R6/2 mouse [96]. Here, SLC12A5 is linked to Huntington disease.