SLC12A2 and Huntington disease: Dargaei and colleagues noted that previous proteomics and interactomics analyses suggested that KCC2 may be associated with HTT [93,94], and that bioinformatics analysis of the unfolded protein response (UPR)-regulated genes in HD have also revealed a reduction in KCC2 transcripts, but an elevation in NKCC1 transcripts [95].