PWAR5 and central nervous system cancer: Since it has been reported that PAR5 suppresses cell growth and migration by direct binding EZH2 in glioma cells, regulating the expression of its targets [23], we performed RNA immunoprecipitation (RIP) assays using specific EZH2 antibody in FRO and 8505c cells in order to confirm that the same mechanism occurs also in thyroid cancer system.