Since it has been reported that PAR5 suppresses cell growth and migration by direct binding EZH2 in glioma cells, regulating the expression of its targets [23], we performed RNA immunoprecipitation (RIP) assays using specific EZH2 antibody in FRO and 8505c cells in order to confirm that the same mechanism occurs also in thyroid cancer system. The gene discussed is EZH2; the disease is central nervous system cancer.