The natural naphthoquinone shikonin 4 suppressed cellular proliferation and induced caspase-dependent apoptosis in BL cells with inhibition of c-MYC and suppression of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway [13]. The gene discussed is AKT1; the disease is Burkitt lymphoma.