PRF1 and hereditary cancer: In addition to mutations associated with risk of hereditary cancer, pathogenic/likely pathogenic mutations were detected in ERCC2 (n = 1), FANCA (n = 1), FANCC (n = 1), HNF1A (n = 1), PRF1 (n = 1) RECQL4 (n = 2), WRN (n = 1), and XPA (n = 1).