As shown in Figure 3E,F, the presence of LLC/luc BM 2nd cells, but not the parental LLC/luc cells, was detected in the bone marrow one day after injecting the mice I.C. Co-culture of the parental LLC/luc cells with lumican also resulted in the detection of cancer cells one day after injecting them I.C. These results suggest that the seeding of parental LLC/luc cells into the bone microenvironment was enhanced after co-culture with exogenous lumican. The gene discussed is LUM; the disease is cancer.