TIMP3 and pancreatic neoplasm: On a co-culture of pancreatic tumor cells and stellate cells that mimics epithelial–stromal interactions, treatment of M402 significantly decreased the invasive behavior in a dose-dependent manner, whereas in vivo it extended survival and reduced metastasis by reducing the protein levels of matrix metalloprotease 1 and by increasing the tissue inhibitor of metalloproteinase 3 (TIMP3) [171].