Subsequently, a double-blind, placebo-controlled randomized study on the effects (modification of the Nugent score, i.e., a Gram stain scoring system for vaginal swabs to diagnose BV) of the oral administration of such lactic acid bacteria and lactoferrin combination in women with intermediate vaginal microbiota confirmed that, in the presence of bovine lactoferrin, both L. acidophilus LMG S-29159 and L. rhamnosus SD5675 are able to colonize vagina. This evidence concerns the gene LTF and bacterial vaginosis.