The association of these two factors with cancer metastasis could be corroborated in the LEC-prostate cancer model, where we found a strong up-regulation of CCL7 and CXCL6 in LECs after interaction with the metastatic cell line LNCAP, but not after co-culture with the non-metastatic cell line DU145. Here, CXCL6 is linked to Familial prostate cancer.