This narrative review is based on original articles and reviews published over the last years and retrieved through PubMed using the following search terms (or combination of terms): NETs, neutrophils, NE, MPO, inflammation, NLRP3 inflammasome, acute myocardial infarction, ST elevation myocardial infarction, obesity, type 1 diabetes, type 2 diabetes, and outcomes. Here, MPO is linked to obesity due to melanocortin 4 receptor deficiency.