This is consistent with a previous study that showed that the replication of GLV-1h68 (a VV-tk gene deleted OVV) in A-549 cells was one of the highest among the 74 cancer cell lines tested; in contrast, the replication of GLV-1h68 in the NCI-H460 cells was at the lower end of the cell panel [31]. The gene discussed is TKT; the disease is cancer.