CD274 and neoplasm: If PD-L1 binds to these lymphocytes, tyrosine dephosphorylases (SHP-1, SHP-2, etc.)gather into the intracellular part of the immune checkpoint molecules and inhibit tyrosine phosphorylation of ZAP70, resulting in T cell dysfunction and the induction of apoptosis thereby suppressing excessive anti-tumor immune responses [18].