CD274 and neoplasm: The mechanisms controlling tumor escape from immunosurveillance are diverse and include downregulation or loss of expression of MHC I molecules, which are essential for CD8+ cytotoxic T cell recognition [28,29], and increased expression of cytotoxic T cell inhibitory ligands, such as programmed cell death ligand 1 (PD-L1), which suppresses cytotoxic T cell attack [30] (Figure 3).