LRP1B and neoplasm: The other mutations were missense, and included two chromatin remodeling genes, BRWD1 and MLLT3, and also LRP1B. The chromosomal microarray in this tumor showed a complex pattern with multiple chromosomal gains, LOH and only few losses, including a heterozygous loss of CDKN2A/B locus (Figure 4E and Table S3).