KLF4 and neoplasm: Mutations have been found to correlate with tumor location and histologic variant: mutations of TRAF7, KLF4, SMO, POLR2A, and AKT1 have been found to correlate with a skull base location [4,5,6] whereas mutations of SMARCE1, BAP1 or a combination of TRAF7 and KLF4 mutations have been shown to be associated with clear cell, rhabdoid or secretory variants, respectively [5,7,8,9].