No pathogenic mutations were found in known genes involved in sporadic or familial meningioma SMO, POLR2A, SMARCB1, SMARCE1, PIK3CA, PIK3R1, AKT3, PTEN, MEN1, and PRKAR1A [4,5,6,8,9]. The gene discussed is SMO; the disease is familial meningioma.