In fact, it was shown that SLMP53-1 triggered a p53-dependent mitochondrial apoptotic cell death in cancer cells, involving upregulation of BAX and PUMA expression levels (considered a consequence of the stimulation of both pro-oxidant and mitochondrial p53 functions [28]), mitochondrial membrane potential dissipation, p53 and BAX mitochondrial translocation, cytochrome c release, and p53-dependent ROS generation [24]. The gene discussed is CYCS; the disease is cancer.