NFKB1 and type 2 diabetes mellitus: AGEs could also contribute to T2DM progression, not only due their oxidant properties per se, but also by triggering the cascade of oxidative damage and inflammatory response through the action of receptors such as nuclear factor kappa B (NFkB), nuclear factor erythroid 2-related factor 2 (Nrf2) and more specifically the receptor for AGEs (RAGE) [29].