In their seminal paper, Jaiswal et al. analyzed whole exome sequencing from 4726 patients with coronary heart disease (CHD) and 3529 controls and found that possessing a CHIP mutation imparted a 2-fold increase in the risk of incident CHD, and a 4-fold increase in the risk of early-onset myocardial infarction [51]. This evidence concerns the gene STUB1 and coronary artery disorder.