This theory was investigated by the PARAGON-HF (Prospective Comparison of ARNI With ARB Global Outcomes in HF With Preserved Ejection Fraction) trial, using a combination of valsartan and the neprilysin inhibitor sacubitril, which increases PKG levels by enhancing availability of brain natriuretic peptide (BNP). Here, PRKG1 is linked to hydrops fetalis.