CXCR3 and hydrops fetalis: Interestingly, there is evidence to support the involvement of the CXCR3–CXCL10 axis in human HF as well, since higher circulating levels of CXCL10 [71] and increased myocardial infiltration of CXCR3+ cells [19] have been described in end-stage HFrEF patients.