Interestingly, most of these proteins were secreted in large amounts by PSC-2 and PSC-5, whereas the secretomes from PCC-3 and PCC-4 displayed significantly lower amounts of various integrins, ezrin, and MET, factors that are known to induce the activation of various signaling pathways leading to migration of cancer cells (Figure 5C,D). Here, EZR is linked to cancer.