IFNG and infection: Previous studies have shown that mice with impaired IFN-γ signaling produce lower levels of inflammatory cytokines and chemokines in the CNS, resulting in better food intake and less weight loss than their WT counterparts, but entry of fewer antibody-secreting cells, slower clearance of infectious virus and more reactivation of infectious virus 18 to 21 days after infection [6,7,8,9].