LIPE and Insulin resistance: This rosemary diterpene compound also suppresses 4-HNE-induced phosphorylation of protein kinase A (p-PKA) and hormone-sensitive lipase (HSL) and attenuates 4-HNE-induced down-regulation of p-AMPK and acetyl-CoA carboxylase, demonstrating the alleviation of insulin resistance driven by 4-HNE [16].