In an intracerebroventricular-streptozotocin-induced AD-type model of rats with cognitive impairment, naringenin increases GST, glutathione peroxidase (GSH-Px), glutathione reductase (GR), superoxide dismutase (SOD), and catalase (CAT) to detoxify 4-HNE in the hippocampus [38]. This evidence concerns the gene GSR and Alzheimer disease.