A prospective study examining frozen tissue qRT-PCR of AQP1, DDX11, BAIAP2L1, and six previously identified genes (PBRM1, BAP1, SETD2, KDM5C, FOXC2, and CLIP4) showed that expression of DDX11 was a significant factor for predicting tumor aggressiveness based on Fuhrman grade. The gene discussed is KDM5C; the disease is neoplasm.