Recent article by Wach et al. reported the RNA sequencing of collecting duct carcinoma, a rare renal cell carcinoma subtype with a very poor prognosis and solute carrier (SLC) gene family (SLC3A1, SLC9A3, SLC26A7, and SLC47A1) was included in the most downregulated genes [24]. This evidence concerns the gene SLC3A1 and hereditary clear cell renal cell carcinoma.