To overcome these limitations and validate our findings, a prospective clinical trial is now underway (ClinicalTrials.gov Identifier: NCT03694912) that will include an examination of the mutation profiles of the selected genes (PBRM1, BAP1, SETD2, KDM5C, FOXC2, CLIP4, MOCOS, BAIAP2L1, DDX11, and AQP1) for aggressive ccRCC. This evidence concerns the gene FOXC2 and nonpapillary renal cell carcinoma.