TYK2 and lung carcinoma: Yu et al., (2015) reported that eriocalyxin B inhibited both constitutive- and interleukin-6 (IL-6)-induced phosphorylation of STAT-3 in A549 lung cancer cells without affecting the upstream kinases such as JAK1, JAK2, and tyrosine kinase 2 (TYK2) [39].