Indeed, analysis of two FH-deficient cell lines—UOK 262 and NCCFH1—as well as FH-deficient tumor, showed strong succination of various, functionally important proteins, including glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and Kelch-like ECH-associated protein 1 (Keap1) [11]. This evidence concerns the gene FH and neoplasm.