NFKB1 and cancer: Various proinflammatory adipocytokines such as interleukin (IL)-6, IL-8, and monocyte chemoattractant protein-1 (MCP-1) can promote the activation and transcription of many protumor signaling pathways such as nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3), resulting in increased migratory and invasive capacities in the adjacent cancer cells [6].