In Chihuahua, we found haplotypes with frequencies higher than 1.0% and the most frequent were HLA-A*01:01-B*08:01-DRB1*03:01-DQB1*02:01 (HF = 2.27%), followed by A*24:02-B*39:01-DRB1*04:07-DQB1*03:02 (HF = 1.70%). This evidence concerns the gene HLA-A and hydrops fetalis.