Secretion of proinflammatory mediators such as cytokines and chemokines (G-CSF, GM-CSF, IL-1α, IL1β, IL-6, IL-8, and CCL5) by epithelial cells, signal the recruitment of phagocytic cells, including neutrophils, macrophages and dendritic cells (DCs) to the site of infection [109,110,111,112,113,114]. The gene discussed is IL1A; the disease is infection.