Additionally, a subset of Th17 cells called CD4+ “natural” Th17 cells (nTh17) residing in the mucosal tissue secrete IL-1, thus mediating antifungal protective immunity in the beginning of infection, since priming of naïve Th cells into effector Th17 cells and recruitment to the site of infection take time [135,138,139]. Here, CD4 is linked to infection.