Over-expression of ESRP1 in COLO320DM cells resulted in an increase in seven proteins including alpha-2-macroglobulin-receptor-associated protein (LRPAP1), a multifunctional endocytic receptor recently identified as a hub within a biomarker network for multi-cancer clinical outcome prediction; splicing factor 3A subunit 1 (SF3A1), which may be up-regulated in head and neck cancers, rectal carcinomas, and human non-small and small-cell lung cancers; Fas-binding factor 1(FBF1) and Trigger transposable element-derived protein 7 (TIGD7) (Figure 1B) [17,18]. The gene discussed is SF3A1; the disease is head and neck cancer.