ESRP1 and neoplasm: Epithelial Splicing Regulatory Protein (ESRP1) is an epithelial cell-specific RBP and splicing factor, which has been described as a tumor suppressor in several studies due to its role in negatively regulating Epithelial-to-Mesenchymal Transition (EMT), for instance, in breast and pancreatic cancer, in oral squamous cell and non-small cell lung carcinomas [5,6,7,8].